Title
Carboxymethyl cellulose esters as stabilizers for hydrophobic drugs in aqueous medium
Authors
MOHAMED EL-SAKHAWY AHMED SALAMA SAMIR KAMEL and HEBAT-ALLAH S. TOHAMY

Received July 12, 2017
Published Volume 52 Issue 9-10 October-December
Keywords bagasse, amphiphilic cellulose, carboxymethyl cellulose acetate butyrate, hydrophobic drug, amorphous solid dispersion, sulfadiazine

Abstract
In the present study, amphiphilic polymers, carboxymethyl cellulose acetate (CMCA) and carboxymethyl cellulose acetate butyrate (CMCAB), with hydrophobic and hydrophilic moieties, were prepared from cellulose extracted from bagasse. The prepared amphiphilic celluloses were characterized by Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). These esters were investigated as stabilizers of sulfadiazine drug in water dispersion. The results showed that CMCAB had higher drug loading efficiency than CMCA.