Title
ATR-FTIR and thermal behavior studies of new hydrogel formulations based on hydroxypropyl methylcellulose/poly(acrilic acid) polymeric blends
Authors
MIRELA-FERNANDA ZALTARIOV DANIELA FILIP CRISTIAN-DRAGOS VARGANICI and DOINA MACOCINSCHI

Received Dedicated to the 70^th anniversary of Acad. Bogdan C. Simionescu
Published Volume 52 Issue 7-8 July-August
Keywords hydroxypropyl methylcellulose, fluconazole β-cyclodextrin inclusion complex, ATR-FTIR, thermogravimetric analysis

Abstract
Stimuli-responsive drug delivery polymeric systems based on physical interactions between all the components: Hydroxypropyl methylcellulose (HPMC) and Poly(acrylic acid) (PAA) loaded with anise/fluconazole β-cyclodextrin (FCZ-β-CD) inclusion complexes, in 1:2 and 1:3 ratios, were prepared and characterized by temperature-dependent ATR-FTIR spectroscopy, DSC and TGA analyses. The successful embedding of the FCZ-β-CD inclusion complex into polymeric matrices was evidenced by IR spectroscopy and DSC data. The H-bonding interactions between HPMC and PAA were found to be stronger by increasing the HPMC content in the gel formulations, while EH varied from 21.29 kJ to 25.89 kJ. The DSC thermograms and TG/DTG curves revealed several endotherms and multiple degradation stages, respectively, because the studied hydrogels were multicomponent systems with complex interactions among all the constituents.