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Title
A polymer-drug system based on regenerated cellulose used in textile industry
Authors
Ciprian Murariu Alina Murariu Marta Harnagea Sorin Ciovica Corina Cheptea and Valeriu Sunel
Received
November 10, 2009
Published
Volume 44 Issue 7-8 July-August
Keywords
cellulose sponges, immobilization of indazole derivatives, polymeric biocomposite material, water
Abstract
Biocompatible absorptive materials with porous structure, formed by cavities with different sizes, have many medical applications, such as drug carriers, base for cell regeneration, implants for tissue regeneration. The immobilization of synthesized indazole derivatives with germicidal, aseptic and anti-inflammatory activity, by diffusion into a regenerated cellulose matrix is studied. The rheological properties of the new composite material are studied, considering the mechanical properties of the materials with potential use in shoe manufacturing for diabetic foot diseases. The immobilization of indazole derivatives onto the cellulose matrix is influenced by certain parameters, like the derivatives/cellulose ratio and cavity structure of the cellulose matrix. New polymer-drug blend systems with medical benefits were obtained and the most important physico- mechanical properties of the new composite, such as water retention and tensile strength, were studied.
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