Title
Assessment of Sba-16 adsorption capacity towards active substances with different chemical structures
Authors
MARIUS NICULAUA BOGDAN I. CIOROIU ALINA M. TOMOIAGA MONA E. CIOROIU and MIHAI I. LAZAR

Received October 8, 2015
Published Volume 51 Issue 1-2 January-February
Keywords glucosaminoglycans, analytical function, adhesive bonding, mesoporous materials, silica particles

Abstract
Mesoporous silica was used for the determination of the encapsulating capacity of different active pharmaceutical substances. The type of support was SBA-16, which has the particularity of having spherical morphology and 3D cubic arrangement of pores. The matrix showed high throughput for the encapsulation of piroxicam and two types of glucosaminoglycans (chondroitin and glucosamine sulfate). The type of intermolecular forces was hydrogen bonding, which permitted the use of the material without any supplementary functionalization. The capacity of the material was demonstrated to range from 197 mg for piroxicam to 375 mg for chondroitin sulfate and 473 mg for glucosamine sulfate. The process of encapsulation was affected by temperature and the optimum contact time was 60 minutes. Structural evaluation was performed using SEM, TGA and FTIR procedures and the evaluation of intake was determined by HPLC methods. Piroxicam stability was evaluated by mass spectrometry testing.