Title
Optimization of drug release from chitosan-starch crosslinked beads by response surface methodology
Authors
KAMLESH KUMARI BAHADUR SINGH and VIRPAL SINGH

Received August 5, 2014
Published Volume 50 Issue 9-10 October-December
Keywords chitosan, starch, controlled drug release, crosslinking, response surface methodology (RSM)

Abstract
The objectives of this study are to investigate and optimize the effect of relative concentrations of chitosan-starch, crosslinkers (sodium hexametaphosphate (SHMP) and glutaraldehyde) and the release time on release of chlorpheniramine maleate (CPM) at pH values of 2.2 and 7.4 by using response surface methodology. The process is optimized with the aim to achieve maximum drug release. The influence of each parameter is studied by factorial design analysis. Analysis of variance (ANOVA) is also used to evaluate the validity of the model. The optimum conditions obtained are 60% chitosan, 40% starch, 10% SHMP, 15% GA concentration and 6.25 h time for drug release at pH values of 2.2 and 7.4, corresponding to the optimum amounts of drug release of 117.7×10-4 g /ml and 121.2×10-4 g/ml, respectively. These optimized values agree with the predicted results, thus indicating the utility of the predictive models in determining the release of CPM in colon specific drug delivery systems.