Title
Cellulose hydrogel sheets for wound dressings
Authors
SANDRA KISELIOVIENE ODETA BANIUKAITIENE VOLODYMYR HARKAVENKO NATALIYA A. BABENKO and JOLANTA LIESIENE

Received May 8, 2015
Published Volume 50 Issue 9-10 October-December
Keywords cellulose, hydrogel, wound dressing, transparent, antibacterial

Abstract
Transparent sheets of regenerated cellulose hydrogels for wound dressing were prepared by hardening hydrolysed cellulose acetate in the designed forms in an acetone solution. The produced sheets were saturated with glycerol to improve their features. The moisture retention, which hinders scab formation, promotes re-epithelialization and accelerates healing process, has been studied. It was determined that the regenerated cellulose hydrogel sheets incorporated with glycerol can retain moisture for a long time. Adhesion properties for imitated wound surfaces were investigated by measuring the maximum force of adhesion, the total work of adhesion and the distance necessary to detach the hydrogel sheets from the imitated wound surface. Incorporation with glycerol lowered the adhesion parameters and showed that these hydrogel sheets would be non-adhesive. Cellulose-based hydrogel sheets were loaded with an antibiotic neomycin and showed good antibacterial properties. The sheets have potential to be used as a wound dressing material with good transparency, mechanical, antibacterial properties.