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Title
Entrapment of flaxseed extract into xanthan-chitosan complex
Authors
DAN DRAGANESCU MIHAELA SILION IOANA IGNAT CECILIA SARGHIE and MARCEL IONEL POPA
Received
September 6, 2012
Published
Volume 47 Issue 3-4 March-April
Keywords
flaxseed extract, chitosan, xanthan, lignans
Abstract
This paper aimed at developing a procedure for the entrapment of flaxseed extract into xanthan-chitosan polyionic
complex and studying the kinetic aspects of its in vitro release. The total phenolic content, radical scavenging activity
and the concentration of delivered secoisolariciresinol (SECO) were determined. The release of SECO from the Xa-CS
complex was studied both in aqueous hydrochloric acid solution (pH = 2.0) and in phosphate buffer (pH = 7.4). The
study revealed two distinct periods in SECO delivery process in an alkaline medium: an initial period, located in the
range of 0 to 8 h, characterized by a high release rate with a delivered SECO amount of approximately 66.5% relative
to the incorporated polyphenol and a second period, from 8 to 24 h (up to 81.5% released), when the release process
was described by a low and constant rate with a linear profile of the kinetic curve, characteristic of zero-order kinetics.
Under acidic conditions, the delivery took place in the first 9 h, with approximately 90.5% of the entrapped SECO
being released.
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