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Title
Synthesis and antimicrobial activity of new amidic derivatives of 5-nitroindazol-1-yl acetic acid encapsulated into alginate/pectin particles
Authors
CORINA CHEPTEA MIHAELA HOLBAN CRISTIAN PEPTU CATALINA LIONTE VALERIU SUNEL MARCEL POPA and JACQUES DESBRIERES
Received
March 27, 2012
Published
Volume 47 Issue 1-2 January-February
Keywords
5-nitroindazol, amide, sodium alginate, pectin, microcapsules, antibacterial activity
Abstract
New amidic compounds with biologic activity, derived from 5-nitroindazol-1-yl-acetic acid have been synthesised and
their chemical structure was confirmed by elemental and spectral analysis (FT-IR, 1
H-NMR, 13C-NMR and mass spectrometry). The incorporation of some of the amides into sodium alginate and pectin based microcapsules, prepared
by polymer ionotropic gelation in O/W emulsion determined the augmentation of their antibacterial potential against
bacterial strains.
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