Cellulose Chemistry and Technology

Title
Polyurethane-hydroxypropyl cellulose membranes for sustained release of nystatin
Authors
MIHAELA MANDRU STELIAN VLAD CONSTANTIN CIOBANU LAURENT LEBRUN and MARCEL POPA

Received November 12, 2012
Published Volume 47 Issue 1-2 January-February
Keywords polyurethane membrane, hydroxypropyl cellulose, nystatin, sustained release

Abstract
The characteristics of two series of polyurethane (PU) membranes with hydroxypropyl cellulose and butane diol were evaluated for sustained release of drug. The entrapping of the nystatin in a polymer matrix provides an approach to kill bacteria and to prevent infection. The polymers used for this study were synthesized from polycaprolactone diol (PCL) as polyol, 4,4’-diphenyl methane diisocyanate (MDI) or methylene-bis(4-cyclohexylisocyanate) (known as H12MDI) as diisocyanate components and 1,4-butane diol (BD) or hydroxypropyl cellulose (HPC) as chain extender. The polymernystatin membranes with BD or HPC were obtained by the phase inversion method. The membranes were characterized by ATR-FTIR, DSC, UV-VIS and contact angle measurements. The sustained release of nystatin depends mainly on the diisocyanate nature of polyurethanes and also on the introduction of hydroxypropyl cellulose in the polyurethane matrix. An in vitro technique to determine the release of nystatin in buffer phosphate (pH=7.4) was used. The possibility of application of these polyurethane-hydroxypropyl cellulose membranes with nystatin was shown by biological test.