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Title
Synthesis and characterization of new heterocyclic compounds with potential antituberculosis activity and their immobilization on polymer supports
Authors
RADITA APARASCHIVEI MIHAELA HOLBAN VALERIU SUNEL MARCEL POPA and JACQUES DESBRIERES
Received
February 9, 2011
Published
Volume 46 Issue 5-6 June-July
Keywords
2-mercapto-benzoxazole derivatives, hydrazides, drug–polymer conjugates, tuberculosis inhibitors
Abstract
New biologically active compounds, obtained by synthesizing new hydrazides derived from benzoxazolyl-2- mercaptoformic acid, respectively benzoxazolyl-2-mercaptoacetic acid, have been chemically immobilized onto poly(maleic anhydride-alt-vinyl acetate) supports, forming drug-polymer conjugates with controlled delivery. The reaction products were characterized by elemental and spectral analyses (FT-IR, 1H-NMR). Toxicological and tuberculostatic activity tests recommend certain reaction products as therapeutic candidates with pharmacological application.
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