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Title
Inclusion complexes of promethazine with monochlorotriazinyl-B-cyclodextrin
Authors
OCTAVIAN POPESCU and AURELIA GRIGORIU
Received
March 21, 2012
Published
Volume 46 Issue 5-6 June-July
Keywords
promethazine, monochlorotriazinyl-?-cyclodextrin, UV spectra, Benesi-Hildebrand equation
Abstract
Formation of inclusion complexes of monochlorotriazinyl-?-cyclodextrin with promethazine was studied, for establishing the optimal conditions of their formation, in view of subsequent grafting on cellulose textiles with potential medicinal use. The infrared spectral study of inclusion in solid state indicated that the complex can be even formed by physically mixing the two substances. By the co-precipitation method, one can obtain a complex with obvious spectral changes, compared to the spectra of the two substances viewed separately. The stability constants of the complex in aqueous medium, in both acid and alkaline environment, were established by means of UV spectra and Benesi- Hildebrand equation. The value of the stability constant obtained is ten times higher in acid than in alkaline medium, which indicates that the alkaline medium is more favourable for producing the complex.
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