|
Title
Chitosan/montmorillonite composites as matrices for prolonged delivery of some novel nitric oxide donor compounds based on theophylline and paracetamol
Authors
ANCA COJOCARIU LENUTA PORFIRE CATALINA CHEABURU and CORNELIA VASILE
Received
January 21, 2011
Published
Volume 46 Issue 1-2 January-February
Keywords
chitosan, montmorillonite, NO-donor drugs, paracetamol, theophylline, drug release, kinetics
Abstract
Chitosan-montmorillonite nanocomposite hydrogels were prepared by crosslinking chitosan nanocomposites with glutaraldehyde. The following types of clays have been used: Cloisite 15A, Cloisite 93A, Dellite HPS and Dellite 67G. The swelling behaviour of the crosslinked hydrogels containing nanoparticles was followed in acidic media with pH = 2.2. These hydrogels have been loaded with paracetamol, theophylline, two xanthine derivatives 7-[2-hydroxy-3-(4- acethyl-amino-phenoxy)-propyl]-8-R-1,3-dimethyl-xanthine derivatives (with R=H and NO for D and respectively 2 1 D ) and two corresponding new nitric oxide donors (NO-donors) as 7-[2-nitroxyacethyl-oxy-3-(4-acethyl-amino- 2 phenoxy)-propyl]-8-R-1,3-dimethyl-xanthine compounds (R=H, NO for 65 and respectively 77 compounds), their 2 controlled release being also evaluated in an acidic solution (pH = 2.2) simulating gastric fluid. The swelling and release kinetics was studied. It has been established that almost all releases involve a non-Fickian or an anomalous transport mechanism.
Link
|
