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Title
Enhanced antipyretic activity of new 25-substituted 134- oxadiazoles encapsulated in alginate/gelatin particulated systems
Authors
CORINA CHEPTEA V. SUNEL MIHAELA HOLBAN J. DESBRIERES M. POPA and CATALINA LIONTE
Received
June 9, 2011
Published
Volume 46 Issue 1-2 January-February
Keywords
1,3,4-oxadizoles, antipyretic activity, encapsulation, polymeric particles
Abstract
New 1,3,4-oxadiazoles with pharmacological potential, derived from 5-nitroindazole, have been synthesized. Their chemical structure has been established by elemental and spectral analyses (FT-IR and 1H-NMR). The oxadiazoles presented low toxicity, one compound, either in a free form or loaded in polymeric microcapsules, also showing a remarkable antipyretic activity, similar to that of acetylsalicylic acid.
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