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Title
New approaches in hydrogel synthesis - click chemistry
Authors
A. ULINIUC M. POPA T. HAMAIDE and M. DOBROMIR
Received
September 12, 2011
Published
Volume 46 Issue 1-2 January-February
Keywords
“click chemistry”, polysaccharide, crosslinking, hydrogel, catalyst-free
Abstract
Hydrogels have attracted great attention over the past decades, since they can be used for a variety of applications, including drug delivery systems and scaffolds for tissue engineering and repair. “Click chemistry”, in particular copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC), has been widely used in the preparation of complex architectures, such as hydrogel networks, due to its reaction specificity, quantitative yields and good functional group tolerance. The aim of this review is to present the synthesis and further use of “click” hydrogels composed of primarily natural components, using Cu as a catalyst or, following the latest trends, via a copper-free method.
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