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Title
Novel acyl derivatives of N-(p-aminobenzoyl)-L-glutamine encapsulated in polymeric nanocapsules with potential antitumoral activity
Authors
Delia Grebinisan Mihaela Holban V. Sunel M. Popa J. Desbrieres and Catalina Lionte
Received
April 18, 2011
Published
Volume 45 Issue 9-10 November-December
Keywords
L-glutamine derivatives, polymers, nanocapsules, antitumoral activity, EAT, chitosan
Abstract
New compounds with antitumoral activity have been obtained, by synthesizing aminoacid derivatives with formyl or acetyl groups grafted on N-(p-aminobenzoyl)-L-glutamine. The suggested chemical structure of the new compounds was confirmed by elemental and spectral analysis (FT-IR and 1H-NMR). The synthesized acyl derivatives have been encapsulated into polymeric nanocapsules, based on chitosan and sodium alginate. Similarly to a reference cytostatic drug (methotrexate), biological tests showed that all compounds and all loaded nanocapsules presented low toxicity and good antitumoral activity against Erlich ascetic tumour in mice.
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