ISSN 2457-9459 (Online)
ISSN-L 0576-9787 (Print)
2023
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Journal Citation Reports |
Impact factor 2023: 1.3
5-Year Impact Factor: 1.2
Article Influence® Score: 0.140
Ranked 9 out of 23
MATERIALS SCIENCE, PAPER & WOOD (Q2) |
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Scopus |
CiteScore 2023: 2.3
SNIP: 0.405 |
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SCImago |
SJR: 0.264
H-Index: 42
Ranked Q3 |
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Title
Synthesis and characterization of a new starch ester with N-[(N -tiazolyl)-p - (benzenesulphone)] amide of N-(o-nitrobenzoyl)-DL-asparagic acid
Authors
Mihaela Holban Valeriu Sunel Marcel Popa and Catalina Lionte
Received
October 25, 2010
Published
Volume 45 Issue 3-4 March-April
Keywords
starch, sulfonamide, polymer-drug system, controlled release
Abstract
The paper studies the dicyclohexylcarbodiimide-activated coupling reaction through ester-type covalent bonds of a sulfonamide derived from N-(m-nitrobenzoyl)-L-asparagic acid on starch. The amount of sulfonamide chemically-bonded to the support is dependent on the reaction parameters, the maximum coupling efficiency being attained at the highest values of the reaction parameters (DCC/sulfonamide molar ratio, sulfonamide/starch molar ratio and reaction time). The kinetics of drug release from the conjugates is studied under alkaline hydrolysis conditions. The conjugates present low toxicity and medium level antimicrobial activity against E. coli and S. aureus strains.
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