ISSN 2457-9459 (Online)
ISSN-L 0576-9787 (Print)
2023
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Journal Citation Reports |
Impact factor 2023: 1.3
5-Year Impact Factor: 1.2
Article Influence® Score: 0.140
Ranked 9 out of 23
MATERIALS SCIENCE, PAPER & WOOD (Q2) |
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Scopus |
CiteScore 2023: 2.3
SNIP: 0.405 |
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SCImago |
SJR: 0.264
H-Index: 42
Ranked Q3 |
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Title
Carboxymethylation of guar gum: synthesis and characterization
Authors
G. Dodi D. Hritcu and M. I. Popa
Received
November 9, 2011
Published
Volume 45 Issue 3-4 March-April
Keywords
guar gum, chemical modification, carboxymethyl group, drug delivery
Abstract
Recent studies focus on the chemical modification of polysaccharides for biomedical applications. Guar gum is a natural polymer composed of linear chains of (1-4)-?-D mannopyranosyl units with ?-D- galactopyranosyl units attached by (1-6) linkages, in a ratio of about 1.5-2, possessing hydroxyl groups available for the attachment of biologically active compounds. The modifications here discussed include the introduction of carboxymethyl groups into the molecule, for extending the applications of partially carboxymethylated guar gum. The carboxymethylation conditions with respect to the volume and concentration of sodium hydroxide, weight of chloro-acetic acid and reaction temperature were optimized. The resulting products were characterized by NMR and FTIR spectroscopy and by thermal gravimetric analysis (TGA). The carboxymethylated guar gum may provide an efficient alternative approach for the oral delivery of hydrophilic macromolecules.
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